Study of co-relation between Chromatin Dynamics and Epigenetic Modifications. The main emphasis of this lab is to unravel the unique epigenetic manipulations during development and tumorigenesis as well as studying the co-relation among reversible H3K4 methylation (–mono,-di,-tri), H3K9 Acetylation and DNA methylation in normal cellular state and malignancy. |
Regulation of epigenetic machineries via micro-RNA mediated gene control Research in our lab is mainly employed in identifying the microRNAs that target DNMTs and Histone modifying enzymes for creating new strategies in the field of cancer diagnosis and prognosis as novel miRNA based drugs and biomarkers. |
Computational Approach to Epigenomics Study
The lab employs bioinformatic tools in directing the selection of key experiments, formulating new testable hypotheses through detailed analysis of complex genomic information and studying of molecular dynamics to further our understanding of transcriptional regulation, nuclear organization, development and disease. |
Demystifying the DNA demethylase enigma The lab is currently focused in unraveling the active mechanism of DNA demethylation catalyzed by an active DNA demethylase enzyme for therapeutic applications in cancer treatment, in solving the human infertility problems, in addressing the dilemma of epigenetic engineering of induced pluripotent stem cells. |
Deciphering the role of HDACs in human cancer
The lab is involved in unravelling the mechanism of tumor suppressor gene silencing and in designing specific HDAC inhibitors which may include synthetic drugs, phytochemicals to achieve re-expression of tumor suppressor genes as an effective cancer therapy. |
Role of Epigenetic modifications in Apoptosis
Research in our lab is focused to dissect the role of epigenetic factors in regulation of molecular cascade of apoptosis so as to have a clear understanding of the molecular mechanism behind the regulation of these pathways and develop new therapeutic approaches in cure of diseases. |